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Who Should NOT Take TRUVADA for PrEP?

DO NOT take TRUVADA for PrEP if you are:

  • HIV-1 positive or unsure of your HIV-1 status
  • Not willing to commit to adopting safer sex practices, such as regular and correct use of condoms, limiting your number of sexual partners, knowing the HIV-1 status of your sexual partners, and regular testing for HIV-1 (at least every 3 months) and other sexually transmitted infections (such as syphilis and gonorrhea)
  • Taking any of the following medications:
    • Epivir-HBV (lamivudine)
    • HEPSERA (adefovir)

What is TRUVADA?

TRUVADA is a prescription medicine that can be used to help reduce the risk of getting HIV-1 infection when used together with safer sex practices. This use is only for adults who are at high risk of getting HIV-1 through sex. This includes HIV-negative men who have sex with men and who are at high risk of getting infected with HIV-1 through sex, and male-female sex partners when one partner has HIV-1 infection and the other does not.

Ask your healthcare provider if you have questions about how to prevent getting HIV-1. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.


Important Safety Information

What is the most important information I should know about TRUVADA?

TRUVADA can cause serious side effects:

  • Too much lactic acid in your blood (lactic acidosis), which is a serious medical emergency. Symptoms of lactic acidosis include weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, nausea, vomiting, stomach-area pain, cold or blue hands and feet, feeling dizzy or lightheaded, and/or fast or abnormal heartbeats.
  • Serious liver problems. Your liver may become large and tender, and you may develop fat in your liver. Symptoms of liver problems include your skin or the white part of your eyes turns yellow, dark “tea-colored” urine, light-colored stools, loss of appetite for several days or longer, nausea, and/or stomach-area pain.
  • You may be more likely to get lactic acidosis or serious liver problems if you are female, very overweight (obese), or have been taking TRUVADA for a long time. In some cases, these serious conditions have led to death. Call your healthcare provider right away if you have any symptoms of these conditions.
  • Worsening of hepatitis B (HBV) infection. If you also have HBV and take TRUVADA, your hepatitis may become worse if you stop taking TRUVADA. Do not stop taking TRUVADA without first talking to your healthcare provider. If your healthcare provider tells you to stop taking TRUVADA, they will need to watch you closely for several months to monitor your health. TRUVADA is not approved for the treatment of HBV.

Before taking TRUVADA to reduce your risk of getting HIV-1 infection:

  • You must be HIV-negative before you start taking TRUVADA. You must get tested to make sure that you do not already have HIV-1 infection. Do not take TRUVADA to reduce the risk of getting HIV-1 unless you are confirmed to be HIV-negative.
  • Many HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. If you have flu-like symptoms, you could have recently become infected with HIV-1. Tell your healthcare provider if you had a flu-like illness within the last month before starting TRUVADA or at any time while taking TRUVADA. Symptoms of new HIV-1 infection include tiredness, fever, joint or muscle aches, headache, sore throat, vomiting, diarrhea, rash, night sweats, and/or enlarged lymph nodes in the neck or groin.

While taking TRUVADA to reduce your risk of getting HIV-1 infection:

  • Just taking TRUVADA may not keep you from getting HIV-1. You must continue using safer sex practices while you are taking TRUVADA to reduce your risk of getting HIV-1.
  • You must stay HIV-negative to keep taking TRUVADA to reduce your risk of getting HIV-1.
  • To further help reduce your risk of getting HIV-1:
    • Know your HIV-1 status and the HIV-1 status of your partners.
    • Get tested for HIV-1 at least every 3 months or when your healthcare provider tells you.
    • Get tested for other sexually transmitted infections. Other infections make it easier for HIV-1 to infect you.
    • Get information and support to help reduce risky sexual behavior.
    • Have fewer sex partners.
    • Do not miss any doses of TRUVADA. Missing doses may increase your risk of getting HIV-1 infection.
    • If you think you were exposed to HIV-1, tell your healthcare provider right away.
  • If you do become HIV-1 positive, you need more medicine than TRUVADA alone to treat HIV-1. TRUVADA by itself is not a complete treatment for HIV-1. If you have HIV-1 and take only TRUVADA, your HIV-1 may become harder to treat over time.

The information in this section is intended for healthcare providers in the United States. To continue to this section, click YES. Click NO to return to the previous page.


The information in this section is intended for HIV educators in the United States.


To continue to this section, click here


To get information for uninfected individuals, click here


To get information for healthcare providers, click here

The information on this site is intended for residents of the United States who are 18 years of age or older.

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