TRUVADA for Pre-Exposure Prophylaxis (PrEP)

TRUVADA is indicated in combination with safer sex practices for PrEP to reduce the risk of sexually acquired HIV-1 in adults at high risk. This indication is based on clinical trials in men who have sex with men (MSM) at high risk for HIV-1 infection and in heterosexual serodiscordant couples.

  • Uninfected individuals at high risk for sexually acquired HIV-1 infections include:
    • individuals with HIV-1 infected partner(s)
    • individuals who engage in sexual activity in a high prevalence area or social network and have one or more of the following: inconsistent or no condom use, diagnosis of sexually transmitted infections (STIs), exchange of sex for commodities (money, food, shelter, drugs), use of illicit drugs or alcohol dependence, incarceration, and/or sexual partners of unknown HIV status with any of the above risk factors.
  • Prescribing considerations before initiating TRUVADA for PrEP:
    • TRUVADA for PrEP must only be prescribed as part of a comprehensive prevention strategy because TRUVADA is not always effective in preventing the acquisition of HIV-1 infection.
    • Uninfected individuals must strictly adhere to their dosing schedule because the effectiveness of TRUVADA in reducing the risk of acquiring HIV-1 is strongly correlated with adherence.
    • HIV-1 negative status must be confirmed prior to initiating TRUVADA for PrEP and at least every 3 months thereafter.
      • If clinical symptoms of acute HIV-1 infection are present and recent exposures (<1 month) are suspected, delay initiating TRUVADA for PrEP for at least 1 month until negative HIV-1 status is reconfirmed.
      • Alternatively, negative HIV-1 status can be confirmed with a test approved by the FDA to aid diagnosis of acute or primary HIV-1 infection.

This website is intended to provide information on how TRUVADA for PrEP can be prescribed and used safely and effectively as part of a comprehensive HIV-1 prevention strategy for adults at high risk for sexually acquired HIV-1 infection.1


Prescribe only to HIV-1 negative adult patients.1

Prescribe PrEP only to HIV-negative adults

TRUVADA for PrEP must only be prescribed to individuals confirmed to be HIV-1 negative immediately prior to initiating treatment. Test patients for HIV-1 before initiating TRUVADA for PrEP and at least every 3 months during use.1

Drug resistant HIV-1 variants have been identified with the use of TRUVADA for PrEP following undetected acute HIV-1 infection.1

If symptoms of acute HIV-1 infection are present, do not initiate TRUVADA for PrEP unless patients have been confirmed to be HIV negative.1

Before you prescribe TRUVADA for PrEP, click here.

TRUVADA for PrEP is a once-daily treatment.1

Pre-exposure Prophylaxis (PrEP) is a once-daily treatment

Uninfected individuals must strictly adhere to their dosing schedule to reduce their risk of sexually acquired HIV-1. The efficacy of TRUVADA is strongly correlated with adherence as demonstrated by measurable drug levels in two clinical trials.1

Learn more about the PrEP clinical trials.

Find out more about comprehensive prevention strategies.

Monitor your patients at least every 3 months.1

HIV-1 testing and monitoring

Patients must be tested regularly for HIV-1 and other
sexually transmitted infections. There may be other tests you
will want to consider.1

Report adverse events and suspected or confirmed HIV seroconversions by calling Gilead at 1-800-GILEAD-51-800-GILEAD-5.

Read more about ongoing monitoring.

Offer free HIV testing to eligible uninsured or underinsured patients at high risk.

Complete the fields below to register for subsidized testing for qualified uninsured or underinsured patients.

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Terms and Conditions

I understand that Gilead Sciences is offering subsidized HIV-1 testing for individuals who may not otherwise have access to testing due to lack of insurance coverage and/or financial hardship and who are being evaluated for TRUVADA for PrEP as part of a comprehensive HIV prevention strategy that includes counseling, safer sex strategies including the use of condoms, and testing before the initiation of TRUVADA for PrEP using a diagnostic test capable of detecting acute HIV-1 infection and HIV-1 antibody testing at least every 3 months while using TRUVADA for PrEP as described in the TRUVADA Prescribing Information.

I understand that Gilead Sciences is also offering subsidized HBV testing for these individuals prior to initiating TRUVADA for PrEP. It is recommended that all individuals be tested for the presence of chronic hepatitis B virus (HBV) before initiating TRUVADA. TRUVADA is not approved for the treatment of chronic HBV infection and the safety and efficacy of TRUVADA have not been established in patients infected with HBV. Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HBV and HIV-1 and have discontinued TRUVADA. In some patients infected with HBV and treated with emtricitabine, the exacerbations of hepatitis B were associated with liver decompensation and liver failure. Patients who are infected with HBV should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment with TRUVADA. If appropriate, initiation of anti-hepatitis B therapy may be warranted. HBV-uninfected individuals should be offered vaccination.

By clicking “I agree” in the box below, I agree to utilize subsidized testing only for the purposes described above and where not otherwise prohibited by law.

Thank you.

You have now registered to receive HIV testing at no cost for uninsured or underinsured patients at high risk. The free test is only available to U.S. patients, excluding Massachusetts residents and beneficiaries of any state or federally funded programs (including, by way of example, Medicare or Medicaid, Medigap, VA, DOD, or TriCare).

LabCorp will contact you with more information.

If you have not received your account information and testing request/lab form to access free HIV and HBV tests within two (2) business days, or have misplaced your account information, please contact LabCorp at 1-800-598-04971-800-598-0497 Please allow staff 1 hour to return any messages.

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